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Courses - Spring 2019
BIOE
Bioengineering Department Site
BIOE120
(Perm Req)
Biology for Engineers
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: Must have completed or be concurrently enrolled in MATH140.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Introduction to the functions and interactions of biological systems from a quantitative perspective. Introduction to the modern experimental techniques and methods of data analysis. Roles for bioengineers in biology, and the role of biology in bioengineering will be elucidated.
BIOE121
(Perm Req)
Biology for Engineers Laboratory
Credits: 1
Grad Meth: Reg, P-F, Aud
Prerequisite: Must have completed or be concurrently enrolled in BIOE120.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Bioengineering encompasses numerous sub-disciplines that apply engineering principles to analyze biological systems and that utilize engineering design strategies to solve biological and biomedical problems. This course is aimed at providing students with the opportunity to learn how biology and engineering can synergistically contribute to our understanding of such problems, and to gain hands-on experience in basic techniques relevant to Bioengineering.
BIOE221
(Perm Req)
Academic and Career Planning
Credits: 1
Grad Meth: Reg
Prerequisite: BIOE120 and BIOE121.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Provides practical tools to help Bioengineering majors think critically about their goals and career paths. Guides Bioengineering students through accessing useful resources both on- and off-campus.
BIOE232
(Perm Req)
Bioengineering Thermodynamics
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: PHYS261 and PHYS260.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE232, ENES232, ENME232, or ENME320.
A quantitative introduction to thermodynamic analysis of bioengineering systems. Bioengineering encompasses a wide range of applications from nanoscale interactions (e.g. reactions between molecules), to cellular interactions (e.g. membrane electrical currents), to overall balances on organisms, all the way to large scale manufacturing. Each of these applications (and many others not mentioned) involve energy interactions which is the domain of thermodynamics. The basic laws of thermodynamics will be introduced and explained through a series of examples related to bioengineering systems.
BIOE241
(Perm Req)
Biocomputational Methods
Credits: 3
Grad Meth: Reg, P-F, Aud
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Application of computer technology to biological and natural resource systems considering engineering aspects. Designed to help students in the use of computer technology for problem solving. The course will cover 4-5 software packages important for later use by the student.
BIOE331
(Perm Req)
Credits: 3
Grad Meth: Reg
Prerequisite: MATH246, BIOE120, BIOE121, and BIOE241; and must have completed or be concurrently enrolled in BIOE232.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE331, ENCE305, or ENME331.
Principles and applications of fluid mechanics with a focus on bioengineering topics. Content includes conservation of mass, momentum, and energy, as well as the application of these fundamental relations to hydrostatics, control volume analysis, internal and external flow, and boundary layers. Applications to biological and bioengineering problems such as tissue engineering, bioprocessing, imaging, and drug delivery.
BIOE332
(Perm Req)
Transport Process Design
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: MATH246, BIOE120, BIOE121, and BIOE241; and must have completed or be concurrently enrolled in BIOE331 or ENME331.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Fluid flow, heat transfer, and mass transfer with applications in medicine, environment, biotechnology, food, agriculture, and other biosystems. Design of solutions to current problems in biological engineering is emphasized.
BIOE340
(Perm Req)
Modeling Physiological Systems and Lab
Credits: 4
Grad Meth: Reg, P-F, Aud
Prerequisite: BSCI330, BIOE120, BIOE121, BIOE241, and MATH246.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE340 or (BSCI440 and BSCI441).
Topics covered will include cell and general physiology, membrane physiology, blood cells and clotting, circulation, metabolism, respiration, and the nervous system. A lab component will also be included.
BIOE371
(Perm Req)
Linear Systems and Ordinary Differential Equations for Bioengineering Applications
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: Must have completed or be concurrently enrolled in MATH246.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
This class utilizes fundamentals in linear systems, including eigenvalues and eigenvectors, as well as linear differential equations, to study various problems in bioengineering and biological systems, with a particular emphasis on feedback, stability, controllability, and control design.
BIOE372
(Perm Req)
Biostatistics for Experimental Design and Data Analysis
Credits: 3
Grad Meth: Reg
Prerequisite: BIOE120, BIOE121, and BIOE241.
Recommended: MATH246.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE372 or STAT464.
This course will instruct students in the fundamentals of probability and statistics through examples in biological phenomenon, the design of bioengineering experiments, and clinical data analysis. Fundamentals covered in the course include probability distributions, hypothesis testing, power analysis, regression analysis, and correlation analysis.
BIOE389C
(Perm Req)
Special Projects in Bioengineering; Bioengineering Design Competitions
Credits: 1
Grad Meth: Reg, P-F
BIOE389 cannot be used as a technical elective towards the BIOE curriculum requirements.
BIOE389F
(Perm Req)
Special Projects in Bioengineering; iGEM Research Seminar
Credits: 2
Grad Meth: Reg, P-F, Aud
Also offered as BSCI338F. Credit granted for BSCI338F or BIOE389F.

This course is open to iGEM team members to develop a synthetic biology research project for the internatial Genetically Engineered Machines competition.
BIOE399
(Perm Req)
Independent Study in Bioengineering
Credits: 1 - 3
Grad Meth: Reg, P-F, Aud
Prerequisite: permission of department.
Contact department for information to register for this course.
BIOE399H
(Perm Req)
Independent Study in Bioengineering
Credits: 1 - 3
Grad Meth: Reg, P-F, Aud
Contact department for information to register for this course.
BIOE411
(Perm Req)
Tissue Engineering
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: Must have completed at least one biology course; and (BIOE120, BIOE121, BIOE241, MATH246, and MATH241). Or permission of ENGR-Fischell Department of Bioengineering department.
Recommended: BSCI330 and BIOE340.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Also offered as: CHBE487.
Credit only granted for: BIOE411 or CHBE487.
A review of the fundamental principles involved in the design of engineered tissues and organs. Both biological and engineering fundamentals will be considered.
BIOE420
(Perm Req)
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: MATH246, BIOE120, BIOE121, and BIOE241.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Examines the physical principles behind major biomedical imaging modalities and new ways of using images for bio-related applications.
BIOE431
(Perm Req)
Fundamentals of Biosensor Techniques, Instrumentation, and Applications
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: CHEM135, PHYS260, PHYS261, BSCI330, BIOE120, BIOE121, BIOE241, and MATH246; or permission of ENGR-Fischell Department of Bioengineering department.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
A thorough review of fundamental concepts of biosensing systems, principles of common detection methods, and modern applications of biosensors. Primarily literature driven. Students will obtain a detailed understanding of cutting-edge biosensing techniques, the instrumentation used, and the application space. Students also will develop skills in using current literature as a source of knowledge.
BIOE437
(Perm Req)
Computer-Aided Design in Bioengineering
Credits: 3
Grad Meth: Reg, Aud
Prerequisite: BIOE120, BIOE121, BIOE241, and MATH246; or permission of ENGR-Fischell Department of Bioengineering department.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE437, BIOE689V, ENME414, ENME272, or ENAE488D.
Formerly: BIOE689V.
Introduction to Computer-Aided Design (CAD). Basic CAD operations will be demonstrated in class with Creo Parametric (formerly Pro/E). Lecture topics will summarize design methodology, review best-practices in hardware development, and discuss engineering applications. The course will culminate in a student-selected project leveraging CAD.
BIOE453
(Perm Req)
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: CHEM231, MATH246, CHEM232, BIOE120, BIOE121, and BIOE241.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE453, CHBE457, or ENMA425.
Examination of the structure and function of natural biomaterials, and cell-extracellular matrix interactions. Study physical properties of synthetic biomaterials for biomedical applications. Understanding molecular level interactions between biomolecules and biomaterials to design novel biomaterials with desirable characteristics. Application of biomaterials as implants, drug delivery systems, biosensors, engineered materials such as artificial skin and bone growth scaffolds will be covered.
BIOE457
(Perm Req)
Biomedical Electronics & Instrumentation
Credits: 4
Grad Meth: Reg, P-F, Aud
Prerequisite: BIOE120, BIOE121, BIOE241, PHYS261, MATH246, and PHYS260.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Students learn fundamental concepts of electronics, assembly of electronic components into functional circuits, and integration of functional electronic devices and circuits into a system. In the lab component, students will learn to assemble and evaluate circuits and systems.
BIOE461
(Perm Req)
Synthetic Biology and Biological Engineering
Credits: 3
Grad Meth: Reg
Prerequisite: BIOE120, BIOE121, BIOE241, and MATH246; or permission of ENGR-Fischell Department of Bioengineering department.
Recommended: Completion of BSCI222 and/or BSCI330 recommended.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE489G or BIOE 461.
Formerly: BIOE489G.
Students are introduce to the scientific foundation and concepts of synthetic biology and biological engineering. Current examples that apply synthetic biology to fundamental and practical challenges will be emphasized. The course will also address the societal issues of synthetic biology, and briefly examine interests to regulate research in this area.
BIOE463
(Perm Req)
Spatial Control of Biological Agents
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: BIOE120, BIOE121, BIOE241, and MATH246; and must have completed or be concurrently enrolled in BIOE332. Or permission of ENGR-Fischell Department of Bioengineering department.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Description and solution of the movement of passive and active biological agents in homogeneous and heterogeneous bioenvironments using partial differential equations and numerical methods. Identification and diagnosis of hot spots. Prescription of control strategies using techniques from Artificial Intelligence (AI) and verification of effectiveness. Applications environments may include landscapes and tissues.
BIOE486
(Perm Req)
Capstone Design II
Credits: 3
Grad Meth: Reg, P-F, Aud
CORE: CS
Prerequisite: Must have completed BIOE485 in the immediately preceding semester.
Restriction: Senior standing; and must be in Engineering: Bioengineering program; and permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE486 or ENBE486.
Formerly: ENBE486.
This is the second part of the senior capstone design course. This part is independent instruction where faculty mentoring each project team works with students to order supplies, fabricate their proposed design under BIOE485, test the design, write the report and present it to their fellow seniors and board of faculty mentors. Students are taught to convert the blue print of a design to actual device and test it.
BIOE489E
(Perm Req)
Special Topics in Bioengineering; Entrepreneurship in Chemical and Life Sciences
Credits: 3
Grad Meth: Reg, P-F, Aud
Also offered as CHEM498E and ENES498E. Credit granted for BIOE489E or ENES498E or CHEM498E.
BIOE489F
(Perm Req)
Special Topics in Bioengineering; CFD/FEA Applications in Bioengineering
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisites: BIOE120, BIOE121, MATH241, BIOE241; recommended: BIOE489C.Covers Computational Fluid Dynamics (CFD) and Finite Element Analysis (FEA) as applicable to Bioengineering.
BIOE489H
(Perm Req)
Special Topics in Bioengineering; BIOE Honors Seminar
Credits: 1 - 3
Grad Meth: Reg, P-F, Aud
BIOE489I
(Perm Req)
Special Topics in Bioengineering; Optical Microscopy
Credits: 3
Grad Meth: Reg, P-F, Aud
Prereqs: BIOE120, BIOE121, BIOE241, MATH246. Co-requisite: BIOE371.

Optical Microscopy includes a large variety of techniques central in many fields of biological and engineering research as well as clinical medicine. This course will provide a comprehensive overview of the fundamentals of optical microscopy. At a fundamental level, we will understand the interaction of light with tissue, cells and biomaterials and we willlearn the mathematical foundations to describe optical systems.
BIOE489T
(Perm Req)
Special Topics in Bioengineering; Biopharmaceutical Process Development and Manufacturing
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: BIOE120.
BIOE489V
(Perm Req)
Special Topics in Bioengineering; Cardiovascular Engineering
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisites: BIOE120, BIOE241, MATH246, BIOE331, BIOE340 An overview of engineering applications in the cardiovascular system. Covers cardiovascular anatomy, physiology and pathophysiology in the context of cell and tissue mechanics, fluid mechanics, thermodynamics, biotransport, neurovascular coupling, and imaging. Includes design of cardiovascular devices, sensors, biomaterials, and tissue engineered constructs.
BIOE489Z
(Perm Req)
Special Topics in Bioengineering; Macro-scale Biomechanics
Credits: 3
Grad Meth: Reg, P-F, Aud
Prereqs: BIOE120, BIOE121, BIOE241, MATH246, ENES102.
BIOE606
(Perm Req)
BIOE Graduate Studies II
Credits: 1
Grad Meth: Reg, Aud
Restriction: Must be in ENGR: PhD Only-Bioengineering (Doctoral) program.
Second semester continued acclimation to the bioengineering graduate program. Students gain exposure to departmental research through lab rotation and to current research in the field through seminar.
BIOE608
(Perm Req)
Bioengineering Seminar Series
Credits: 1
Grad Meth: Reg, Aud
Restriction: Must be in one of the following programs (ENGR: PhD Only-Bioengineering (Master's); ENGR: PhD Only-Bioengineering (Doctoral)).
BIOE632
(Perm Req)
Biophotonic Imaging and Microscopy
Credits: 3
Grad Meth: Reg, Aud
Recommended: BIOE420.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE432, BIOE632, or BIOE689C.
Principles and instrumentation of various biomedical optical techniques including fluorescene and Raman spectroscopy, confocal and multi-photon microscopy, optical coherence tomography, and diffuse optical tomography. Biomedical aplications will also be discussed.
BIOE658I
(Perm Req)
Special Topics in Bioengineering (M.Eng.); Medical Imaging and Image Processing
Credits: 3
Grad Meth: Reg, Aud
For Master of Engineering students only or with permission of department.

This course is an introduction to biomedical imaging and image analysis. In this course, the fundamental physical principles behind the four primary medical imaging modalities - computed tomography, magnetic resonance imaging, ultrasound and nuclear medicine imaging - will be introduced. Introduction of each imaging modality will also include the clinical interpretation of images it produces. This course will also introduce medical image processing and new and emerging ways of using medical images for diagnosis and treatment.
BIOE658P
(Perm Req)
Special Topics in Bioengineering (M.Eng.); Physiology for Bioengineers
Credits: 3
Grad Meth: Reg, Aud
For Master of Engineering students only or with permission of department. Credit will only be granted for BIOE658P or BIOE689M.

This course is aimed at providing the background biological knowledge for bioengineers to successfully assess the potential patho-physiological impact of their designs on biological systems. Course material focuses on cellular biology, signal transduction, the immune system, inflammation, and hemostasis.
BIOE658W
(Perm Req)
Special Topics in Bioengineering (M.Eng.); Biosensor Techniques, Instrumentation, and Applications
Credits: 3
Grad Meth: Reg, Aud
For Master of Engineering students only or with permission of department. Credit will only be granted for BIOE658W, BIOE631, or BIOE431.

A thorough review of fundamental concepts of biosensing systems, principles of common detection methods, and modern applications of biosensors. Primarily literature driven. Students will obtain a detailed understanding of cutting-edge biosensing techniques, the instrumentation used, and the application space. Students also will develop skills in using current literature as a source of knowledge.
BIOE689
(Perm Req)
Special Topics in Bioengineering
Credits: 1 - 3
Grad Meth: Reg
Contact department for information to register for this course.
BIOE689A
(Perm Req)
Special Topics in Bioengineering; Engineering Approaches to Photomedicine
Credits: 3
Grad Meth: Reg
This course will introduce students to the fundamentals of photophysics, photochemistry, and photobiology. Engineering of selective photosensitizers, optically active nanomedicine and alternative light sources for photodynamic therapy, photothermal therapy, and imaging will be covered. Other light-based therapies, including laser surgery, low-level light therapy, and light-activated tissue repair and regeneration, will also be featured. The course will briefly cover radiation, magnetic, and ultrasound-based technologies to highlight other extrinsic activation mechanisms for drug delivery and phototherapy. Students will have the opportunity to review and present research articles on these emerging phototherapies and participate in lab experiments to gain a greater awareness of current advancements and refine skills in literature review.
BIOE689K
(Perm Req)
Special Topics in Bioengineering; Cardiovascular Engineering
Credits: 3
Grad Meth: Reg
An overview of engineering applications in the cardiovascular system. Covers cardiovascular anatomy, physiology and pathophysiology in the context of cell and tissue mechanics, fluid mechanics, thermodynamics, biotransport, neurovascular coupling, and imaging. Includes design of cardiovascular devices, sensors, biomaterials, and tissue engineered constructs.
BIOE689N
(Perm Req)
Special Topics in Bioengineering; Bionanotechnology
Credits: 3
Grad Meth: Reg
Also offered as ENCH648N. Credit granted for ENCH648N or BIOE689N.
BIOE799
(Perm Req)
Master's Thesis Research
Credits: 1 - 6
Grad Meth: Reg, S-F
Contact department for information to register for this course.
BIOE898
(Perm Req)
Pre-Candidacy Research
Credits: 1 - 8
Grad Meth: Reg, S-F
Contact department for information to register for this course.
BIOE899
(Perm Req)
Doctoral Dissertation Research
Credits: 6
Grad Meth: Reg, S-F
Contact department for information to register for this course.