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Courses - Spring 2023
CHBE
Chemical and Biomolecular Engineering
CHBE680
(Perm Req)
Bionanotechnology: Physical Principles
Credits: 3
Grad Meth: Reg, Aud
Restriction: Permission of ENGR-Chemical & Biomolecular Engineering department.
Jointly offered with: CHBE480.
Credit only granted for: ENCH648N, CHBE480 or CHBE680.
Formerly: ENCH648N.
Physics at nano/micro scales. Biomolecular building blocks. Simplest biomolecular assembly: protein folding. Nanoscale intermolecular interactions important in biology. Protein-ligand binding. Protein higher-order assembly: filaments, networks. Protein filaments and motility. DNA, RNA and their assembly assisted by proteins. Viral capsid assembly. Lipid assembly into micelles, bilayers. Lipid-protein co-assembly in membranes. Lipid and polymer-based carriers useful in medicine. Antimicrobial therapies. Targeted cancer therapy. Ideal properties of nanocarriers in terms of size, charge, and surface chemistry.