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Courses - Spring 2022
BIOE
Bioengineering Department Site
BIOE120
(Perm Req)
Biology for Engineers
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: Must have completed or be concurrently enrolled in MATH140.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Introduction to the functions and interactions of biological systems from a quantitative perspective. Introduction to the modern experimental techniques and methods of data analysis. Roles for bioengineers in biology, and the role of biology in bioengineering will be elucidated.
BIOE121
(Perm Req)
Biology for Engineers Laboratory
Credits: 1
Grad Meth: Reg, P-F, Aud
Prerequisite: Must have completed or be concurrently enrolled in BIOE120.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Bioengineering encompasses numerous sub-disciplines that apply engineering principles to analyze biological systems and that utilize engineering design strategies to solve biological and biomedical problems. This course is aimed at providing students with the opportunity to learn how biology and engineering can synergistically contribute to our understanding of such problems, and to gain hands-on experience in basic techniques relevant to Bioengineering.
BIOE221
(Perm Req)
Academic and Career Planning
Credits: 1
Grad Meth: Reg, P-F
Prerequisite: BIOE120 and BIOE121.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Provides practical tools to help Bioengineering majors think critically about their goals and career paths. Guides Bioengineering students through accessing useful resources both on- and off-campus.
BIOE232
(Perm Req)
Bioengineering Thermodynamics
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: PHYS261 and PHYS260.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE232, ENES232, ENME232, or ENME320.
A quantitative introduction to thermodynamic analysis of bioengineering systems. Bioengineering encompasses a wide range of applications from nanoscale interactions (e.g. reactions between molecules), to cellular interactions (e.g. membrane electrical currents), to overall balances on organisms, all the way to large scale manufacturing. Each of these applications (and many others not mentioned) involve energy interactions which is the domain of thermodynamics. The basic laws of thermodynamics will be introduced and explained through a series of examples related to bioengineering systems.
BIOE241
(Perm Req)
Biocomputational Methods
Credits: 3
Grad Meth: Reg, P-F, Aud
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Application of computer technology to biological and natural resource systems considering engineering aspects. Designed to help students in the use of computer technology for problem solving. The course will cover 4-5 software packages important for later use by the student.
BIOE331
(Perm Req)
Credits: 3
Grad Meth: Reg, P-F
Prerequisite: MATH246, BIOE120, BIOE121, BIOE241, and BIOE371; and must have completed or be concurrently enrolled in BIOE232.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE331, ENCE305, ENFP300 or ENME331.
Principles and applications of fluid mechanics with a focus on bioengineering topics. Content includes conservation of mass, momentum, and energy, as well as the application of these fundamental relations to hydrostatics, control volume analysis, internal and external flow, and boundary layers. Applications to biological and bioengineering problems such as tissue engineering, bioprocessing, imaging, and drug delivery.
BIOE340
(Perm Req)
Modeling Physiological Systems and Lab
Credits: 4
Grad Meth: Reg, P-F, Aud
Prerequisite: BSCI330, BIOE120, BIOE121, BIOE241, and MATH246.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE340 or (BSCI440 and BSCI441).
Topics covered will include cell and general physiology, membrane physiology, blood cells and clotting, circulation, metabolism, respiration, and the nervous system. A lab component will also be included.
BIOE371
(Perm Req)
Linear Systems and Ordinary Differential Equations for Bioengineering Applications
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: BIOE241; and must have completed or be concurrently enrolled in MATH246.
Restriction: Permission on ENGR-Fischell Department of Bioengineering department.
This class utilizes fundamentals in linear systems, including eigenvalues and eigenvectors, as well as linear differential equations, to study various problems in bioengineering and biological systems, with a particular emphasis on feedback, stability, controllability, and control design.
BIOE372
(Perm Req)
Biostatistics for Experimental Design and Data Analysis
Credits: 3
Grad Meth: Reg, P-F
Prerequisite: BIOE120, BIOE121, and BIOE241.
Recommended: MATH246.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE372 or STAT464.
This course will instruct students in the fundamentals of probability and statistics through examples in biological phenomenon, the design of bioengineering experiments, and clinical data analysis. Fundamentals covered in the course include probability distributions, hypothesis testing, power analysis, regression analysis, and correlation analysis.
BIOE389C
(Perm Req)
Special Projects in Bioengineering; Bioengineering Design Competitions
Credits: 1
Grad Meth: Reg, P-F
BIOE389 cannot be used as a technical elective towards the BIOE curriculum requirements.
BIOE389F
(Perm Req)
Special Projects in Bioengineering; iGEM Research Seminar
Credits: 2
Grad Meth: Reg, P-F, Aud
Cross-listed with BSCI338F. Credit granted for BSCI338F or BIOE389F.
BIOE399
(Perm Req)
Independent Study in Bioengineering
Credits: 1 - 3
Grad Meth: Reg, P-F, Aud
Prerequisite: permission of department.
Contact department for information to register for this course.
BIOE399H
Independent Study in Bioengineering
Credits: 1 - 3
Grad Meth: Reg, P-F, Aud
Contact department for information to register for this course.
BIOE413
(Perm Req)
Stem Cell Engineering
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: BIOE241, BIOE120, BIOE121, MATH246, and BIOE340.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Jointly offered with: BIOE613.
Credit only granted for: BIOE489J, BIOE413, BIOE689J or BIOE613.
Formerly: BIOE489J.
Provides an introduction to the role of stem cells in tissue growth and development, the engineering of stem cells and their environments for regenerative medicine applications, and disease modeling. Topics covered will include basic stem cell biology and mechanobiology; experimental methods for growing, differentiating, studying, and characterizing stem cells; stem cell integration into engineered microenvironments (e.g., tissue scaffolds and biomaterials, organ-on-chip devices, 3D-printed biomaterials); stem cell engineering in clinical applications and disease models; and ethical, commercialization, and regulatory issues in the field of stem cell engineering.
BIOE414
(Perm Req)
Macroscale Biomechanics
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: BIOE120, BIOE121, BIOE241, MATH246, and ENES102.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE414 or BIOE489Z.
Formerly: BIOE489Z.
An overview of current problems in movement biomechanics. After taking this course, students will be able to 1) Describe the engineering tools needed to study human movement 2) Recognize a variety of clinical research and practice, and 3) Use the framework provided by the course to pursue their own self-teaching and research on these topics. Topics covered include muscle mechanics, joint mechanics, EMG and EEG signal applications, ultrasonography and elastography, anthropometry, human movement 3-D kinematics, inverse dynamics, forward dynamics, work, power and energy. Biomechanics tools will be used to investigate clinical problems. Students will also do research projects on related topics.
BIOE437
(Perm Req)
Computer-Aided Design in Bioengineering
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: BIOE120, BIOE121, BIOE241, and MATH246; or permission of ENGR-Fischell Department of Bioengineering department.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE437, BIOE689V, ENME414, ENME272, or ENAE488D.
Formerly: BIOE689V.
Introduction to Computer-Aided Design (CAD). Basic CAD operations will be demonstrated in class with Creo Parametric (formerly Pro/E). Lecture topics will summarize design methodology, review best-practices in hardware development, and discuss engineering applications. The course will culminate in a student-selected project leveraging CAD.
BIOE442
(Perm Req)
Python: Introduction to Programming and Data Analysis
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: BIOE241, BIOE120, BIOE121, and MATH241; or permission of ENGR-Fischell Department of Bioengineering department.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE489A or BIOE442.
Formerly: BIOE489A.
Provides an introduction to structured programming, computational methods, and data analysis techniques with the goal of building a foundation allowing students to confidently address problems in research and industry. Fundamentals of programming, algorithms, and simulation are covered from a general computer science perspective, while the applied data analysis and visualization portion makes use of the Python SciPy stack.
BIOE447
(Perm Req)
Clinical Experiences in Bioengineering
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: BIOE221.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE489O or BIOE447.
Formerly: BIOE489O.
An immersion experience in the clinical settings in which biomedical engineering strategies, technologies, and practices are applied. An emphasis will be placed on both clinical problems and engineering solutions.
BIOE453
(Perm Req)
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: CHEM231, MATH246, CHEM232, BIOE120, BIOE121, and BIOE241.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE453, CHBE457, or ENMA425.
Examination of the structure and function of natural biomaterials, and cell-extracellular matrix interactions. Study physical properties of synthetic biomaterials for biomedical applications. Understanding molecular level interactions between biomolecules and biomaterials to design novel biomaterials with desirable characteristics. Application of biomaterials as implants, drug delivery systems, biosensors, engineered materials such as artificial skin and bone growth scaffolds will be covered.
BIOE457
(Perm Req)
Biomedical Electronics & Instrumentation
Credits: 4
Grad Meth: Reg, P-F, Aud
Prerequisite: BIOE120, BIOE121, BIOE241, PHYS261, MATH246, and PHYS260.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Students learn fundamental concepts of electronics, assembly of electronic components into functional circuits, and integration of functional electronic devices and circuits into a system. In the lab component, students will learn to assemble and evaluate circuits and systems.
BIOE461
(Perm Req)
Synthetic Biology and Biological Engineering
Credits: 3
Grad Meth: Reg, P-F
Prerequisite: BIOE120, BIOE121, BIOE241, and MATH246; or permission of ENGR-Fischell Department of Bioengineering department.
Recommended: Completion of BSCI222 and/or BSCI330 recommended.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Students are introduce to the scientific foundation and concepts of synthetic biology and biological engineering. Current examples that apply synthetic biology to fundamental and practical challenges will be emphasized. The course will also address the societal issues of synthetic biology, and briefly examine interests to regulate research in this area.
BIOE486
(Perm Req)
Capstone Design II
Credits: 3
Grad Meth: Reg, P-F, Aud
CORE: CS
Prerequisite: Must have completed BIOE485 in the immediately preceding semester.
Restriction: Senior standing; and must be in Engineering: Bioengineering program; and permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE486 or ENBE486.
Formerly: ENBE486.
This is the second part of the senior capstone design course. This part is independent instruction where faculty mentoring each project team works with students to order supplies, fabricate their proposed design under BIOE485, test the design, write the report and present it to their fellow seniors and board of faculty mentors. Students are taught to convert the blue print of a design to actual device and test it.
BIOE488B
(Perm Req)
Research Methods in Bioengineering; Research Methods in Bioengineering: Biotechnology
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisites: BIOE120, BIOE121, BSCI330. Restriction: permission of department.

This course prepares students for a broad range of opportunities by delivering a practical, hands-on experience appropriate for a student interested in biotechnology and pharma. Students will learn techniques appropriate for the production of a biologic. Some of the techniques/unit operations utilized in the course include: Design of Experiments (DOE), tran sformation, media optimization, bioreactor process optimization, centrifugation, dialysis, liquid chromatography, protein quantification and as says. This course is designed to provide the same valuable experience and guidance you would receive in bioproduction research.
BIOE489F
(Perm Req)
Special Topics in Bioengineering; CFD/FEA Applications in Bioengineering
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisites: BIOE120, BIOE121, MATH241, BIOE241; recommended: BIOE489C.Covers Computational Fluid Dynamics (CFD) and Finite Element Analysis (FEA) as applicable to Bioengineering.
BIOE489H
(Perm Req)
Special Topics in Bioengineering; BIOE Honors Seminar
Credits: 1 - 3
Grad Meth: Reg, P-F, Aud
BIOE489Q
(Perm Req)
Special Topics in Bioengineering; Engineering Approaches to Photomedicine
Credits: 3
Grad Meth: Reg, P-F, Aud
Prereqs: BIOE120, BIOE121, BIOE241, and MATH246.

Introduces students to the fundamentals of photophysics, photochemistry, and photobiology. Engineering of selective photosensitizers, optically active nanomedicine and alternative light sources for photodynamic therapy, photothermal therapy, and imaging will be covered. Other light-based therapies, including laser surgery, low-level light therapy,and light-activated tissue repair and regeneration, will also befeatured. The course will briefly cover radiation, magnetic, and ultrasound-based technologies to highlight other extrinsic activation mechanisms for drugdelivery and phototherapy. Students will have the opportunity to review and present research articles on these emerging phototherapies and participate in lab experiments to gain a greater awareness of current advancements and refine skills in literature review.
BIOE489R
(Perm Req)
Special Topics in Bioengineering; Protein Engineering
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: BIOE120 and BIOE232. Credit only granted for: CHBE497, BIOE489R, or ENCH648P.
BIOE489T
(Perm Req)
Special Topics in Bioengineering; Biopharmaceutical Process Development and Manufacturing
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: BIOE120. Credit only granted for: BIOE489T or CHBE474
BIOE489W
(Perm Req)
Special Topics in Bioengineering; Advanced Biomaterials
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: BIOE453 or Permission of the Fischell Department of Bioengineering.

Advanced biomaterials property (viscoelasticity) and its impact on biomedical systems; interactions of proteins and cells (particularly immune and stem cells) with micro, nano, and macroscale biomaterials; and advanced applications of biomaterials for tissue engineering, regenerative medicine, stem cell therapy, drug delivery, and cancer theranostics.
BIOE604
(Perm Req)
Cellular and Physiological Transport Phenomena
Credits: 3
Grad Meth: Reg, Aud
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
A study of transport processes, including momentum, energy and mass transport, relevant to biosystems at various scales from physiological to cellular systems. Transport leads to sets of partial differential equations and the course revolves around approaches to solving these equations to arrive at fundamental understanding of the physics of transport in biosystems.
BIOE606
(Perm Req)
BIOE Graduate Studies II
Credits: 1
Grad Meth: Reg, Aud
Restriction: Must be in ENGR: PhD Only-Bioengineering (Doctoral) program.
Second semester continued acclimation to the bioengineering graduate program. Students gain exposure to departmental research through lab rotation and to current research in the field through seminar.
BIOE608
(Perm Req)
Bioengineering Seminar Series
Credits: 1
Grad Meth: S-F, Aud
Restriction: Must be in one of the following programs (ENGR: PhD Only-Bioengineering (Master's); ENGR: PhD Only-Bioengineering (Doctoral)).
BIOE613
(Perm Req)
Stem Cell Engineering
Credits: 3
Grad Meth: Reg, Aud
Restriction: Permission of ENGR-Fischell Department of Bioengineering.
Jointly offered with: BIOE413.
Credit only granted for: BIOE489J, BIOE413, BIOE689J or BIOE613.
Formerly: BIOE689J.
Provides an introduction to the role of stem cells in tissue growth and development, the engineering of stem cells and their environments for regenerative medicine applications, and disease modeling. Topics covered will include basic stem cell biology and mechanobiology; experimental methods for growing, differentiating, studying, and characterizing stem cells; stem cell integration into engineered microenvironments (e.g., tissue scaffolds and biomaterials, organ-on-chip devices, 3D-printed biomaterials); stem cell engineering in clinical applications and disease models; and ethical, commercialization, and regulatory issues in the field of stem cell engineering.
BIOE658E
(Perm Req)
Special Topics in Bioengineering (M.Eng.); Biomedical Device Development
Credits: 3
Grad Meth: Reg, Aud
For Master of Engineering students only or with permission of department. Credit only granted for BIOE658E or BIOE689W.
BIOE658P
(Perm Req)
Special Topics in Bioengineering (M.Eng.); Physiology for Bioengineers
Credits: 3
Grad Meth: Reg, Aud
For Mastering of Engineering students only or with permission of department. Credit will only be granted for BIOE658P or BIOE689M.

Bioengineering-based designs of biomaterials, biomedical devices, imaging and drug delivery agents, tissue engineering, and prosthesis (among others), offer the opportunity to improve health care. This course is aimed at providing biological knowledge to lead bioengineering designs on the basis of biocompatibility and to provide tools to assess their patho-physiological impact in biological systems.
BIOE658Y
(Perm Req)
Special Topics in Bioengineering (M.Eng.); Applications of Tissue Engineering
Credits: 3
Grad Meth: Reg
Restriction: For Master of Engineering students only; or permission of department. Credit only granted for: BIOE689Y, BIOE658Y, BIOE611, or BIOE411.
BIOE689
Special Topics in Bioengineering
Credits: 1 - 3
Grad Meth: Reg
Contact department for information to register for this course.
BIOE689A
(Perm Req)
Special Topics in Bioengineering; Engineering Approaches to Photomedicine
Credits: 3
Grad Meth: Reg
Credit only granted for BIOE489Q or BIOL689A.

Students are introduced to the fundamentals of photophysics, photochemistry, and photobiology. Engineering of selective photosensitizers, optically active nanomedicine and alternative light sources for photodynamic therapy, photothermal therapy, and imaging will be covered. Other light-based therapies, including laser surgery, low-level light therapy, and light-activated tissue repair and regeneration, will also be featured. The course will briefly cover radiation, magnetic, and ultrasound-based technologies to highlight other extrinsic activation mechanisms for drug delivery and phototherapy. Students will have the opportunity to review and present research articles on these emerging phototherapies and participate in lab experiments to gain a greater awareness of current advancements and refine skills in literature review.
BIOE689T
(Perm Req)
Special Topics in Bioengineering; Advanced Biomaterials
Credits: 3
Grad Meth: Reg, S-F
Restriction: Permission of the Fischell Department of Bioengineering

Advanced biomaterials property (viscoelasticity) and its impact on biomedical systems; interactions of proteins and cells (particularly immune and stem cells) with micro, nano, and macroscale biomaterials; and advanced applications of biomaterials for tissue engineering, regenerative medicine, stem cell therapy, drug delivery, and cancer theranostics.
BIOE799
(Perm Req)
Master's Thesis Research
Credits: 1 - 6
Grad Meth: S-F
Contact department for information to register for this course.
BIOE898
(Perm Req)
Pre-Candidacy Research
Credits: 1 - 8
Grad Meth: Reg
Contact department for information to register for this course.
BIOE899
(Perm Req)
Doctoral Dissertation Research
Credits: 6
Grad Meth: S-F
Contact department for information to register for this course.