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Courses - Fall 2024
BIOI
Bioinformatics and Computational Biology
Open Seats as of
07/18/2024 at 07:30 AM
BIOI601
Probability and Statistics
Credits: 3
Grad Meth: Reg
Prerequisite: Undergraduate courses in calculus and basic linear algebra.
Cross-listed with: DATA601, MSML601.
Credit only granted for: BIOI601, DATA601 or MSML601.
Provides a solid understanding of the fundamental concepts of probability theory and statistics. The course covers the basic probabilistic concepts such as probability space, random variables and vectors, expectation, covariance, correlation, probability distribution functions, etc. Important classes of discrete and continuous random variables, their inter-relation, and relevance to applications are discussed. Conditional probabilities, the Bayes formula, and properties of jointly distributed random variables are covered. Limit theorems, which investigate the behavior of a sum of a large number of random variables, are discussed. The main concepts random processes are then introduced. The latter part of the course concerns the basic problems of mathematical statistics, in particular, point and interval estimation and hypothesis testing.
BIOI602
Principles of Data Science
Credits: 3
Grad Meth: Reg
Restriction: Must be in one of the following programs: (Data Science Post-Baccalaureate Certificate, Master of Professional Studies in Data Science and Analytics, or Master of Professional Studies in Machine Learning).
Cross-listed with: DATA602, MSML602.
Credit only granted for: BIOI602, DATA602, MSML602 or CMSC641.
Formerly: CMSC641.
An introduction to the data science pipeline, i.e., the end-to-end process of going from unstructured, messy data to knowledge and actionable insights. Provides a broad overview of what data science means and systems and tools commonly used for data science, and illustrates the principles of data science through several case studies.
BIOI603
Principles of Machine Learning
Credits: 3
Grad Meth: Reg
Restriction: Must be in one of the following programs: (Data Science Post-Baccalaureate Certificate, Master of Professional Studies in Data Science and Analytics, or Master of Professional Studies in Machine Learning).
Cross-listed with: DATA603, MSML603, MSQC603.
Credit only granted for: BIOI603, DATA603, MSML603, MSQC603 or CMSC643.
Formerly: CMSC643.
A broad introduction to machine learning and statistical pattern recognition. Topics include: Supervised learning: Bayes decision theory, discriminant functions, maximum likelihood estimation, nearest neighbor rule, linear discriminant analysis, support vector machines, neural networks, deep learning networks. Unsupervised learning: clustering, dimensionality reduction, PCA, auto-encoders. The course will also discuss recent applications of machine learning, such as computer vision, data mining, autonomous navigation, and speech recognition.
The lecture may be conducted online some weeks and in person other weeks. Please see ELMS for Class meeting details.
BIOI604
Principles of Molecular Biology, Genetics and Genomics
Credits: 3
Grad Meth: Reg
Provides a review of basic concepts in molecular biology, genetics, and genomics. Topics include the following: prokaryotic and eukaryotic genome structure and organization (including 3D architecture); Mendelian genetics, recombination, linkage and linkage disequilibrium, genome-wide association studies; review of genome projects, comparative genomics, genome variation, single nucleotide polymorphisms and genotyping; gene expression and the transcriptome, transcriptional regulation, gene regulatory networks; translation and translational regulation; proteomics approaches; integrative genomics.
BIOI611
Analysis of Gene Expression Data
Credits: 3
Grad Meth: Reg
Prerequisite: BIOI604.
This course focuses on the analysis of transcriptomics data, and specifically on the analysis of gene and transcript-level expression. Material covered includes transcript and gene expression estimation from RNA-seq data (short and long-read), basic experimental design and statistical methods for differential expression analysis, discovery of novel transcripts via reference-guided and de novo assembly, and the analysis of single-cell gene expression data (e.g., single-cell expression quantification, dimensionality reduction, clustering, pseudotime analysis). Prerequisite: BIOI 604. Core.
BIOI621
Genome Assembly and Annotation
Credits: 3
Grad Meth: Reg
Prerequisite: BIOI604.
An introduction to the algorithms and tools used to reconstruct genome sequences from shotgun sequencing data and to annotate the resulting sequence. Course includes theoretical underpinnings of core assembly paradigms and the practical use of paradigms; approaches for scaffolding the reconstructed sequences along chromosomes using mate-pair and other types of information; and validating sequence assemblers output. The course will discuss approaches for interpreting sequence annotations in the context of a reconstructed genome, focusing on genome browsers and other visualization and analytical tools and approaches for interpreting gene synteny information. A particular focus will be on the impact of repetitive sequences on the quality of genome assemblies and ability to effectively analyze gene synteny and to conduct comparative genomic analyses.