What forces determine whether we live long, healthy lives or face preventable illness? Why do some communities thrive while others struggle with disease? How do environmental factors, workplace conditions, and global systems impact human health and well-being? Become a health detective to unpack those questions and more! From the recent fatal floods in Texas to the global spread of COVID-19, from workplace injuries to heat safety, this course will provide a broad introduction to foundations of epidemiology, toxicology, exposure assessment, risk analysis, policy analysis, digital health, and global health systems. We introduce the One Health approach, which recognizes the interconnection between human health, animal health, and environmental health. Students will investigate the work of scientists, policymakers, and communities as they uncover together how environmental toxins, workplace hazards, and global inequalities create health crises and solutions being developed to protect health worldwide. Through accelerated case studies, interactive discussions, virtual field experiences, and hands-on activities, students will develop critical thinking skills required to evaluate and solve grand health challenges.