The impact of diseases on populations from prehistoric times through the present will be examined, along with public perceptions of disease, scientific breakthroughs on treatment and prevention, and the ways that politics and public health policies can enhance or impede the advancement of disease treatment. The natural history of disease, population structure, and immunity will be discussed. The class will address emerging and re-emerging diseases and the ways that first responders, researchers, and policy makers may affect the outcome of an outbreak.