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Courses - Spring 2025
BIOE
Bioengineering Department Site
Open Seats as of
11/20/2024 at 10:30 PM
BIOE120
(Perm Req)
Biology for Engineers
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: Must have completed or be concurrently enrolled in MATH140.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Introduction to the functions and interactions of biological systems from a quantitative perspective. Introduction to the modern experimental techniques and methods of data analysis. Roles for bioengineers in biology, and the role of biology in bioengineering will be elucidated.
BIOE121
(Perm Req)
Biology for Engineers Laboratory
Credits: 1
Grad Meth: Reg, P-F, Aud
Prerequisite: Must have completed or be concurrently enrolled in BIOE120.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Bioengineering encompasses numerous sub-disciplines that apply engineering principles to analyze biological systems and that utilize engineering design strategies to solve biological and biomedical problems. This course is aimed at providing students with the opportunity to learn how biology and engineering can synergistically contribute to our understanding of such problems, and to gain hands-on experience in basic techniques relevant to Bioengineering.
BIOE221
(Perm Req)
Academic and Career Planning
Credits: 1
Grad Meth: Reg, P-F
Prerequisite: BIOE120 and BIOE121.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Provides practical tools to help Bioengineering majors think critically about their goals and career paths. Guides Bioengineering students through accessing useful resources both on- and off-campus.
BIOE232
(Perm Req)
Bioengineering Thermodynamics
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: PHYS261 and PHYS260.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE232, ENES232, ENME232, or ENME320.
A quantitative introduction to thermodynamic analysis of bioengineering systems. Bioengineering encompasses a wide range of applications from nanoscale interactions (e.g. reactions between molecules), to cellular interactions (e.g. membrane electrical currents), to overall balances on organisms, all the way to large scale manufacturing. Each of these applications (and many others not mentioned) involve energy interactions which is the domain of thermodynamics. The basic laws of thermodynamics will be introduced and explained through a series of examples related to bioengineering systems.
BIOE241
(Perm Req)
Biocomputational Methods
Credits: 3
Grad Meth: Reg, P-F, Aud
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Application of computer technology to biological and natural resource systems considering engineering aspects. Designed to help students in the use of computer technology for problem solving. The course will cover 4-5 software packages important for later use by the student.
BIOE331
(Perm Req)
Credits: 3
Grad Meth: Reg, P-F
Prerequisite: MATH246, BIOE120, BIOE121, BIOE241, and BIOE371; and must have completed or be concurrently enrolled in BIOE232.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE331, ENCE305, ENFP300 or ENME331.
Principles and applications of fluid mechanics with a focus on bioengineering topics. Content includes conservation of mass, momentum, and energy, as well as the application of these fundamental relations to hydrostatics, control volume analysis, internal and external flow, and boundary layers. Applications to biological and bioengineering problems such as tissue engineering, bioprocessing, imaging, and drug delivery.
BIOE340
(Perm Req)
Modeling Physiological Systems and Lab
Credits: 4
Grad Meth: Reg, P-F, Aud
Prerequisite: BSCI330, BIOE120, BIOE121, BIOE241, and MATH246.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE340 or (BSCI440 and BSCI441).
Topics covered will include cell and general physiology, membrane physiology, blood cells and clotting, circulation, metabolism, respiration, and the nervous system. A lab component will also be included.
BIOE371
(Perm Req)
Linear Systems and Ordinary Differential Equations for Bioengineering Applications
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: BIOE241; and must have completed or be concurrently enrolled in MATH246.
Restriction: Permission on ENGR-Fischell Department of Bioengineering department.
This class utilizes fundamentals in linear systems, including eigenvalues and eigenvectors, as well as linear differential equations, to study various problems in bioengineering and biological systems, with a particular emphasis on feedback, stability, controllability, and control design.
BIOE372
(Perm Req)
Biostatistics for Experimental Design and Data Analysis
Credits: 3
Grad Meth: Reg, P-F
Prerequisite: BIOE120, BIOE121, and BIOE241.
Recommended: MATH246.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE372 or STAT464.
This course will instruct students in the fundamentals of probability and statistics through examples in biological phenomenon, the design of bioengineering experiments, and clinical data analysis. Fundamentals covered in the course include probability distributions, hypothesis testing, power analysis, regression analysis, and correlation analysis.
BIOE386
(Perm Req)
Bioengineering Design and Teamwork
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: Minimum grade of C- in BIOE120, BIOE121, BIOE241, and MATH246.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department and must have earned a minimum of 60 credits.
Focuses on the engineering design process, including needs finding, problem definition, inclusive design, and prototyping. Students will join an existing senior capstone design team and contribute to the project. This elective is designed to be taken directly prior to BIOE485, and will collaborate with the students and projects in that course. Students who complete BIOE386 may have the option to continue their capstone project in BIOE485.
BIOE389C
(Perm Req)
Special Projects in Bioengineering; Bioengineering Design Competitions
Credits: 1
Grad Meth: Reg, P-F
BIOE389 cannot be used as a technical elective towards the BIOE curriculum requirements.
BIOE389F
Special Projects in Bioengineering; iGEM Research Seminar
Credits: 2
Grad Meth: Reg, P-F, Aud
Cross-listed with BSCI338F. Credit granted for BSCI338F or BIOE389F.
BIOE389M
(Perm Req)
Special Projects in Bioengineering; Research Skills and Professional Development for MARC Scholars
Credits: 1
Grad Meth: Reg, P-F, Aud
Restricted to students in the Maximizing Access to Research Careers (MARC) Program.

The course will provide instruction and opportunities for development in research skills and scientific communication, along with individualized preparation towards graduate school and a career in biomedical research .
BIOE399
(Perm Req)
Independent Study in Bioengineering
Credits: 1 - 3
Grad Meth: Reg, P-F, Aud
Prerequisite: permission of department.
Contact department for information to register for this course.
BIOE399H
(Perm Req)
Independent Study in Bioengineering
Credits: 1 - 3
Grad Meth: Reg, P-F, Aud
Contact department for information to register for this course.
BIOE404
(Perm Req)
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: MATH246, BIOE120, ENES102, BIOE121, and BIOE241; and must have completed or be concurrently enrolled in BIOE371.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Introduction to the fundamentals of biomechanics including force analysis, mechanics of deformable bodies, stress and strain, multiaxial deformations, stress analysis, and viscoelasticity. Biomechanics of soft and hard tissues.
BIOE413
(Perm Req)
Stem Cell Engineering
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: BIOE241, BIOE120, BIOE121, and MATH246; and must have completed or be concurrently enrolled in BIOE340.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Jointly offered with: BIOE613.
Credit only granted for: BIOE413, BIOE689J, or BIOE613.
Provides an introduction to the role of stem cells in tissue growth and development, the engineering of stem cells and their environments for regenerative medicine applications, and disease modeling. Topics covered will include basic stem cell biology and mechanobiology; experimental methods for growing, differentiating, studying, and characterizing stem cells; stem cell integration into engineered microenvironments (e.g., tissue scaffolds and biomaterials, organ-on-chip devices, 3D-printed biomaterials); stem cell engineering in clinical applications and disease models; and ethical, commercialization, and regulatory issues in the field of stem cell engineering.
BIOE414
(Perm Req)
Macroscale Biomechanics
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: BIOE120, BIOE121, BIOE241, MATH246, and ENES102.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Jointly offered with: BIOE614.
Credit only granted for: BIOE414, BIOE614 or BIOE489Z.
Formerly: BIOE489Z.
An overview of current problems in movement biomechanics. After taking this course, students will be able to 1) Describe the engineering tools needed to study human movement 2) Recognize a variety of clinical research and practice, and 3) Use the framework provided by the course to pursue their own self-teaching and research on these topics. Topics covered include muscle mechanics, joint mechanics, EMG and EEG signal applications, ultrasonography and elastography, anthropometry, human movement 3-D kinematics, inverse dynamics, forward dynamics, work, power and energy. Biomechanics tools will be used to investigate clinical problems. Students will also do research projects on related topics.
BIOE437
(Perm Req)
Computer-Aided Design in Bioengineering
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: BIOE120, BIOE121, BIOE241, and MATH246; or permission of ENGR-Fischell Department of Bioengineering department.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE437, BIOE689V, ENME414, ENME272, or ENAE488D.
Formerly: BIOE689V.
Introduction to Computer-Aided Design (CAD). Lecture topics will summarize design methodology, review best-practices in hardware development, and discuss engineering applications. The course will culminate in a student-selected project leveraging CAD.
BIOE442
(Perm Req)
Python: Introduction to Programming and Data Analysis
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: BIOE241, BIOE120, BIOE121, and MATH241; or permission of ENGR-Fischell Department of Bioengineering department.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE489A or BIOE442.
Formerly: BIOE489A.
Provides an introduction to structured programming, computational methods, and data analysis techniques with the goal of building a foundation allowing students to confidently address problems in research and industry. Fundamentals of programming, algorithms, and simulation are covered from a general computer science perspective, while the applied data analysis and visualization portion makes use of the Python SciPy stack.
BIOE447
(Perm Req)
Clinical Experiences in Bioengineering
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: BIOE221.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE489O or BIOE447.
Formerly: BIOE489O.
An immersion experience in the clinical settings in which biomedical engineering strategies, technologies, and practices are applied. An emphasis will be placed on both clinical problems and engineering solutions.
BIOE453
(Perm Req)
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: CHEM231, MATH246, CHEM232, BIOE120, BIOE121, and BIOE241.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE453, CHBE457, or ENMA425.
Examination of the structure and function of natural biomaterials, and cell-extracellular matrix interactions. Study physical properties of synthetic biomaterials for biomedical applications. Understanding molecular level interactions between biomolecules and biomaterials to design novel biomaterials with desirable characteristics. Application of biomaterials as implants, drug delivery systems, biosensors, engineered materials such as artificial skin and bone growth scaffolds will be covered.
BIOE461
(Perm Req)
Synthetic Biology and Biological Engineering
Credits: 3
Grad Meth: Reg, P-F
Prerequisite: BIOE120, BIOE121, BIOE241, and MATH246; or permission of ENGR-Fischell Department of Bioengineering department.
Recommended: Completion of BSCI222 and/or BSCI330 recommended.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Students are introduce to the scientific foundation and concepts of synthetic biology and biological engineering. Current examples that apply synthetic biology to fundamental and practical challenges will be emphasized. The course will also address the societal issues of synthetic biology, and briefly examine interests to regulate research in this area.
BIOE462
(Perm Req)
Therapeutic Development and Delivery
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: BIOE120, BIOE121, BIOE241, MATH246, and BSCI330; and must have completed or be concurrently enrolled in BIOE340.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE489P or BIOE462.
Formerly: BIOE489P.
The ultimate purpose of the pharmaceutical and biotechnology industries is the development and delivery of therapeutics. This course covers fundamentals of engineering and the pharmaceutical sciences related to therapeutics, including basic pharmaceutics/drug delivery, pharmacokinetics, biomolecular kinetics, and regulatory issues. Specific focus is placed on biotherapeutics, including antibodies and protein engineering,RNA and DNA therapeutics (gene therapy and RNAi), extracellular vesicle biotechnology (exosomes), and cell-based therapies, including stem cells. The use of delivery technologies to enable therapeutics (e.g. nanomedicine) will also be discussed.
BIOE464
(Perm Req)
Introduction to Computational Molecular Bioengineering
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: Minimum grade of C- in BIOE232, BIOE372, and BIOE442; and minimum grade of C- in BIOE371 or BIOE246; or permission of Fischell Department of Bioengineering.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Designed to introduce students to the principles, methods, and software used for simulation and modeling of macromolecules of biological interest such as proteins, lipids, and polysaccharides. Along with experiment and theory, computational modeling provides new tools for analysis, explanation and prediction. The course is also useful for students who plan to use experimental techniques as their primary approach, but who will employ computational modeling as a tool to obtain integrative understanding of complex systems. Finally, the course should be valuable as an introductory overview for students planning to conduct their thesis research in computational modeling of biological systems. Class topics: Basic statistical thermodynamics, Force fields, Molecular dynamics/ monte carlo methods, Conformational analysis, Fluctuations & transport properties, Free-energy calculations, Multiscale modeling.
BIOE486
(Perm Req)
Capstone Design II
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: Must have completed BIOE485 in the immediately preceding semester.
Restriction: Senior standing; and must be in Engineering: Bioengineering program; and permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE486 or ENBE486.
Formerly: ENBE486.
This is the second part of the senior capstone design course. This part is independent instruction where faculty mentoring each project team works with students to order supplies, fabricate their proposed design under BIOE485, test the design, write the report and present it to their fellow seniors and board of faculty mentors. Students are taught to convert the blue print of a design to actual device and test it.
BIOE488A
(Perm Req)
Research Methods in Bioengineering; Molecular Biology
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: BIOE120, BIOE121, and BSCI330. Restriction: Permission of department.

This course prepares students for a broad range of opportunities by delivering a practical, hands-on laboratory experience that mirrors the real world of research. Students will independently investigate a novel topic related to biomedicine; learn the science and theory behind commonresearch methods; and apply those fundamental techniques, protocols, assays, and technologies to their own experiments. Some of the techniques utilized in the course include: microbiology, protein quantification assays, molecular cloning, PCR, DNA sequencing, novel drug discovery andscreening. This course is designed to prove the same valuable experienceand guidance you would receive in a research lab.
BIOE489B
(Perm Req)
Special Topics in Bioengineering; Engineering Cancer
Credits: 3
Grad Meth: Reg, P-F, Aud
Prereqs: BSCI330 or Permission of the Fischell Department of Bioengineering. A course that employs the engineering method to approach grand challenges associated with cancer. This will be done by defining problems traditionally associated with treating cancer cancers, conducting background research to delineate phenomena associated with cancer progression, brainstorming and developing more effective treatments to overcome thesephenomena, and implementing what is learned to treat it to other diseases.
BIOE489F
(Perm Req)
Special Topics in Bioengineering; CFD/FEA Applications in Bioengineering
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisites: BIOE120, BIOE121, MATH241, BIOE241; recommended: BIOE489C.Covers Computational Fluid Dynamics (CFD) and Finite Element Analysis (FEA) as applicable to Bioengineering.
BIOE489H
(Perm Req)
Special Topics in Bioengineering; BIOE Honors Seminar
Credits: 1 - 3
Grad Meth: Reg, P-F, Aud
BIOE489J
(Perm Req)
Special Topics in Bioengineering; Advanced Manufacturing Laboratory (AML)
Credits: 3
Grad Meth: Reg
Prerequisite: BIOE457. Credit only granted for ENEE419M, ENMA489M, or BIOE489J.

An interdisciplinary course designed to provide students with an overview of key processes, technology, and manufacturing techniques involved in fabricating advanced devices and systems. Students will be exposed to state-of-the-art fabrication technologies including soft lithography, 3Dprinting, hybrid manufacturing, material functionalization, and systems integration. In addition to developing a theoretical understanding in the classroom, students will gain hands-on fabrication and characterization experience of systems that can interface with complex environments.
BIOE489Q
(Perm Req)
Special Topics in Bioengineering; Engineering Approaches to Photomedicine
Credits: 3
Grad Meth: Reg, P-F, Aud
Prereqs: BIOE120, BIOE121, BIOE241, and MATH246.

Introduces students to the fundamentals of photophysics, photochemistry, and photobiology. Engineering of selective photosensitizers, optically active nanomedicine and alternative light sources for photodynamic therapy, photothermal therapy, and imaging will be covered. Other light-based therapies, including laser surgery, low-level light therapy,and light-activated tissue repair and regeneration, will also befeatured. The course will briefly cover radiation, magnetic, and ultrasound-based technologies to highlight other extrinsic activation mechanisms for drugdelivery and phototherapy. Students will have the opportunity to review and present research articles on these emerging phototherapies and participate in lab experiments to gain a greater awareness of current advancements and refine skills in literature review.
BIOE489R
(Perm Req)
Special Topics in Bioengineering; Protein Engineering
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: BIOE120 and BIOE232. Credit only granted for: CHBE497, BIOE489R, or ENCH648P.
BIOE606
(Perm Req)
BIOE Graduate Studies II
Credits: 1
Grad Meth: Reg, Aud
Restriction: Must be in ENGR: PhD Only-Bioengineering (Doctoral) program.
Second semester continued acclimation to the bioengineering graduate program. Students gain exposure to departmental research through lab rotation and to current research in the field through seminar.
BIOE608
(Perm Req)
Bioengineering Seminar Series
Credits: 1
Grad Meth: S-F, Aud
Restriction: Must be in one of the following programs (ENGR: PhD Only-Bioengineering (Master's); ENGR: PhD Only-Bioengineering (Doctoral)).
BIOE654
(Perm Req)
Physiology for Bioengineers
Credits: 3
Grad Meth: Reg, Aud
Restriction: Restricted to Master's of Engineering - Bioengineering students; or permission of Fischell Department of Bioengineering.
Credit only granted for: BIOE654 or BIOE658P.
Formerly: BIOE658P.
Bioengineering-based designs of biomaterials, biomedical devices, imaging and drug delivery agents, tissue engineering, and prosthesis (among others), offer the opportunity to improve health care. This course is aimed at providing biological knowledge to lead bioengineering designs on the basis of biocompatibility and to provide tools to assess their patho-physiological impact in biological systems.
BIOE658B
(Perm Req)
Special Topics in Bioengineering (M.Eng.); Introduction to Medical Image Analysis
Credits: 3
Grad Meth: Reg
Restriction: For Master of Engineering students only or with permission of department.

Introduces fundamental topics of medical image analysis, including image enhancement, filtering, feature extraction, segmentation, registration, classification. Topics will be discussed in the context of both traditioanl and deep learning approaches. The course also covers performance metrics and evaluation techniques used by experts in the image analysis communitAlong with digital image processing, this course will review medical imaging modalities, their mechanisms of action, and best practices for modality specific image file types and formats. Students introduced to these topics will learn industry-relevant software and practice digital image processing in MATLAB and Python based environments.
BIOE658E
(Perm Req)
Special Topics in Bioengineering (M.Eng.); Biomedical Device Development
Credits: 3
Grad Meth: Reg, Aud
For Master of Engineering students only or with permission of department. Credit only granted for BIOE658E or BIOE689W.
BIOE689
(Perm Req)
Special Topics in Bioengineering
Credits: 1 - 3
Grad Meth: Reg
Contact department for information to register for this course.
BIOE689A
(Perm Req)
Special Topics in Bioengineering; Engineering Approaches to Photomedicine
Credits: 3
Grad Meth: Reg
Credit only granted for BIOE489Q or BIOL689A.

Students are introduced to the fundamentals of photophysics, photochemistry, and photobiology. Engineering of selective photosensitizers, optically active nanomedicine and alternative light sources for photodynamic therapy, photothermal therapy, and imaging will be covered. Other light-based therapies, including laser surgery, low-level light therapy, and light-activated tissue repair and regeneration, will also be featured. The course will briefly cover radiation, magnetic, and ultrasound-based technologies to highlight other extrinsic activation mechanisms for drug delivery and phototherapy. Students will have the opportunity to review and present research articles on these emerging phototherapies and participate in lab experiments to gain a greater awareness of current advancements and refine skills in literature review.
BIOE689C
(Perm Req)
Special Topics in Bioengineering; Systems Medicine
Credits: 3
Grad Meth: Reg
Prerequisites: MATH246 and BIOE232; or students who have taken courses with comparable content may contact the department.

Students will learn the fundamentals of a physiological system, then create simple basic principles or laws to explain why the system is built the way it is. why it goes wrong or becomes pathologic, and which new strategies might treat them. In particular, we will study diabetes, autoimmune diseases, lung fibrosis, and cancer.
BIOE689N
(Perm Req)
Special Topics in Bioengineering; Network Neuroscience and Brain Dynamic Analysis
Credits: 3
Grad Meth: Reg
This course explores the emerging interdisciplinary field of network neuroscience, integrating concepts from neuroscience, systems engineering, data science, and neural engineering. Students will engage with both classical and modern mathematical models of network sciences, as well as advanced approaches for analyzing brain dynamics. In addition, they will develop skills in peer reviewing journal articles and writing reviewer reports. Students will gain hands-on experience in neuro data analysis by applying these models and analyses to functional neuroimaging datasets such as EEG, LFP, and/or fMRI. The course emphasizes building intuition for the types of problems in brain science that can be addressed through network-based approaches, while also fostering analytical skills and promoting interdisciplinary research through team projects.
BIOE689W
(Perm Req)
Special Topics in Bioengineering; Mastering Scientific Writing: From Grants to Publications
Credits: 3
Grad Meth: Reg
5estrictions: Permission of the Fischell Department of Bioengineering.

Will equip students with essential skills for effective scientific communication. The course covers the distinctions between scientific and other writing styles, persuasive and factual writing, storytelling, and scientific grammar. Students learn to craft clear and concise sentences, structure their work logically, formulate hypotheses, and communicate science to both scientific and lay audiences. Through hands-on practice,feedback, and expert guidance, the goal is to enhance scientific writing abilities for publishing, presentations, and science communication.
BIOE689X
(Perm Req)
Special Topics in Bioengineering; Macroscale Biomechanics
Credits: 3
Grad Meth: Reg
Topics covered include muscle mechanics, joint mechanics, EMG and EEG signal applications, ultrasonography and elastography, anthropometry, human movement 3-D kinematics, inverse dynamics, forward dynamics, work, power and energy. Biomechanics tools will be used to investigate clinical problems.
BIOE799
(Perm Req)
Master's Thesis Research
Credits: 1 - 6
Grad Meth: S-F
Contact department for information to register for this course.
BIOE898
(Perm Req)
Pre-Candidacy Research
Credits: 1 - 8
Grad Meth: Reg
Contact department for information to register for this course.
BIOE899
(Perm Req)
Doctoral Dissertation Research
Credits: 6
Grad Meth: S-F
Contact department for information to register for this course.