The magnitude and complexity of food safety and security challenges necessitate that scientists, researchers, and others look beyond their own disciplines, professions, and mindsets to investigate new organizational modes of team science, and the One Health concept embodies this declaration. One Health is a multidisciplinary effort that works locally, nationally, and globally to achieve optimal health for people, animals, and the environment. This is a collaborative course offered by the University of Maryland and Cairo University in Cairo, Egypt, to investigate One Health and its application to improving international food safety and security. Participants in this global (undergraduate and graduate) class will learn about One Health and how its application can improve global food safety and security. Students will use One Health principles to ensure food safety and security through a global lens. This project-based class provides excellent opportunities for UMD students to interact and collaborate with students from Cairo University and other Egyptian universities using modern methods of international collaboration tools such as zoom technology and others. Synchronous meeting time: Mondays, 10am-12pm EST or 4pm-6pm Egyptian Time; Wednesdays 10am-12pm EST or 4pm-6pm Egyptian Time.