The course is designed for graduate students to understand the impacts of nutrition on human health through the interaction between nutritional molecules and genetic/epigenetic/gut microbial/metabolomic variants in the biological system leading to an optimized health through personalized dietary guidelines. This course will start to introduce the basics of different types of genomic profiles and then focus on how diets and nutrients affect the interplay of these profiles such as genomics, epigenomics, gut microbiome, metabolomics and transcriptomics on human health. We will also discuss the application of precision nutrition technology in prevention or therapy of different types of human diseases (e.g., obesity, diabetes, cancer and age-related human diseases) by discussing cutting-edge research evidence and literatures. Better understating of the interaction between nutrition and different genomic functions can be used to develop personalized dietary guidelines to improve human health.