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Courses - Fall 2024
BIOE
Bioengineering Department Site
Open Seats as of
07/19/2024 at 10:30 PM
BIOE120
(Perm Req)
Biology for Engineers
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: Must have completed or be concurrently enrolled in MATH140.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Introduction to the functions and interactions of biological systems from a quantitative perspective. Introduction to the modern experimental techniques and methods of data analysis. Roles for bioengineers in biology, and the role of biology in bioengineering will be elucidated.
Students will be introduced to the functions and interactions of biological systems from a quantitative perspective. They will also be encourage d to solve problems through active inquiry, critical analysis,and creat ivity. Finally, roles for bioengineers in biology, and the role of biology in bioengineering will be elucidated.
BIOE121
(Perm Req)
Biology for Engineers Laboratory
Credits: 1
Grad Meth: Reg, P-F, Aud
Prerequisite: Must have completed or be concurrently enrolled in BIOE120.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Bioengineering encompasses numerous sub-disciplines that apply engineering principles to analyze biological systems and that utilize engineering design strategies to solve biological and biomedical problems. This course is aimed at providing students with the opportunity to learn how biology and engineering can synergistically contribute to our understanding of such problems, and to gain hands-on experience in basic techniques relevant to Bioengineering.
BIOE221
(Perm Req)
Academic and Career Planning
Credits: 1
Grad Meth: Reg
Prerequisite: BIOE120 and BIOE121.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Provides practical tools to help Bioengineering majors think critically about their goals and career paths. Guides Bioengineering students through accessing useful resources both on- and off-campus.
BIOE232
(Perm Req)
Bioengineering Thermodynamics
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: PHYS261 and PHYS260.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE232, ENES232, ENME232, or ENME320.
A quantitative introduction to thermodynamic analysis of bioengineering systems. Bioengineering encompasses a wide range of applications from nanoscale interactions (e.g. reactions between molecules), to cellular interactions (e.g. membrane electrical currents), to overall balances on organisms, all the way to large scale manufacturing. Each of these applications (and many others not mentioned) involve energy interactions which is the domain of thermodynamics. The basic laws of thermodynamics will be introduced and explained through a series of examples related to bioengineering systems.
BIOE241
(Perm Req)
Biocomputational Methods
Credits: 3
Grad Meth: Reg, P-F, Aud
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Application of computer technology to biological and natural resource systems considering engineering aspects. Designed to help students in the use of computer technology for problem solving. The course will cover 4-5 software packages important for later use by the student.
BIOE331
(Perm Req)
Credits: 3
Grad Meth: Reg
Prerequisite: MATH246, BIOE120, BIOE121, BIOE241, and BIOE371; and must have completed or be concurrently enrolled in BIOE232.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE331, ENCE305, ENFP300 or ENME331.
Principles and applications of fluid mechanics with a focus on bioengineering topics. Content includes conservation of mass, momentum, and energy, as well as the application of these fundamental relations to hydrostatics, control volume analysis, internal and external flow, and boundary layers. Applications to biological and bioengineering problems such as tissue engineering, bioprocessing, imaging, and drug delivery.
BIOE340
(Perm Req)
Modeling Physiological Systems and Lab
Credits: 4
Grad Meth: Reg, P-F, Aud
Prerequisite: BSCI330, BIOE120, BIOE121, BIOE241, and MATH246.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE340 or (BSCI440 and BSCI441).
Topics covered will include cell and general physiology, membrane physiology, blood cells and clotting, circulation, metabolism, respiration, and the nervous system. A lab component will also be included.
BIOE371
(Perm Req)
Linear Systems and Ordinary Differential Equations for Bioengineering Applications
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: BIOE241; and must have completed or be concurrently enrolled in MATH246.
Restriction: Permission on ENGR-Fischell Department of Bioengineering department.
This class utilizes fundamentals in linear systems, including eigenvalues and eigenvectors, as well as linear differential equations, to study various problems in bioengineering and biological systems, with a particular emphasis on feedback, stability, controllability, and control design.
BIOE372
(Perm Req)
Biostatistics for Experimental Design and Data Analysis
Credits: 3
Grad Meth: Reg
Prerequisite: BIOE120, BIOE121, and BIOE241.
Recommended: MATH246.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE372 or STAT464.
This course will instruct students in the fundamentals of probability and statistics through examples in biological phenomenon, the design of bioengineering experiments, and clinical data analysis. Fundamentals covered in the course include probability distributions, hypothesis testing, power analysis, regression analysis, and correlation analysis.
BIOE389M
(Perm Req)
Special Projects in Bioengineering; Research Skills and Professional Development for MARC Scholars
Credits: 1
Grad Meth: Reg, P-F, Aud
Restriction: Must be a student in the Mazimizing Acces to Research Careers (MARC) Program.

The course will provide instruction and opportunities for development in research skills and scientific communication, along with individualized preparation towards graduate school and a career in biomedical research.
BIOE399
(Perm Req)
Independent Study in Bioengineering
Credits: 1 - 3
Grad Meth: Reg, P-F, Aud
Prerequisite: permission of department.
Contact department for information to register for this course.
BIOE399H
(Perm Req)
Independent Study in Bioengineering
Credits: 1 - 3
Grad Meth: Reg, P-F, Aud
Contact department for information to register for this course.
BIOE411
(Perm Req)
Tissue Engineering
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: Must have completed at least one biology course; and (BIOE120, BIOE121, BIOE241, MATH246, and MATH241). Or permission of ENGR-Fischell Department of Bioengineering department.
Recommended: BSCI330 and BIOE340.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE411 or CHBE487.
A review of the fundamental principles involved in the design of engineered tissues and organs. Both biological and engineering fundamentals will be considered.
BIOE413
(Perm Req)
Stem Cell Engineering
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: BIOE241, BIOE120, BIOE121, and MATH246; and must have completed or be concurrently enrolled in BIOE340.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Jointly offered with: BIOE613.
Credit only granted for: BIOE413, BIOE689J, or BIOE613.
Provides an introduction to the role of stem cells in tissue growth and development, the engineering of stem cells and their environments for regenerative medicine applications, and disease modeling. Topics covered will include basic stem cell biology and mechanobiology; experimental methods for growing, differentiating, studying, and characterizing stem cells; stem cell integration into engineered microenvironments (e.g., tissue scaffolds and biomaterials, organ-on-chip devices, 3D-printed biomaterials); stem cell engineering in clinical applications and disease models; and ethical, commercialization, and regulatory issues in the field of stem cell engineering.
BIOE415
(Perm Req)
Engineering Design for Global Health
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: BIOE120, BIOE121, and MATH246.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Jointly offered with: BIOE615.
Credit only granted for: BIOE415, BIOE615, BIOE489Y, or BIOE689I.
Formerly: BIOE489Y.
Many medical technologies are not available in low and middle-income countries due to the cost, infrastructure, and medical expertise required to implement and sustain them. There is tremendous potential to increase access to health care through developing more affordable biomedical technologies, but effective design requires deep understanding of the problem. The goal of this course is to introduce the human-centered design framework and how it can be applied to design new biomedical technologies to solve challenges in global health.
BIOE420
(Perm Req)
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: MATH246, BIOE120, BIOE121, and BIOE241.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Examines the physical principles behind major biomedical imaging modalities and new ways of using images for bio-related applications.
BIOE437
(Perm Req)
Computer-Aided Design in Bioengineering
Credits: 3
Grad Meth: Reg, Aud
Prerequisite: BIOE120, BIOE121, BIOE241, and MATH246; or permission of ENGR-Fischell Department of Bioengineering department.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE437, BIOE689V, ENME414, ENME272, or ENAE488D.
Formerly: BIOE689V.
Introduction to Computer-Aided Design (CAD). Lecture topics will summarize design methodology, review best-practices in hardware development, and discuss engineering applications. The course will culminate in a student-selected project leveraging CAD.
BIOE442
(Perm Req)
Python: Introduction to Programming and Data Analysis
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: BIOE241, BIOE120, BIOE121, and MATH241; or permission of ENGR-Fischell Department of Bioengineering department.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE489A or BIOE442.
Formerly: BIOE489A.
Provides an introduction to structured programming, computational methods, and data analysis techniques with the goal of building a foundation allowing students to confidently address problems in research and industry. Fundamentals of programming, algorithms, and simulation are covered from a general computer science perspective, while the applied data analysis and visualization portion makes use of the Python SciPy stack.
BIOE453
(Perm Req)
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: CHEM231, MATH246, CHEM232, BIOE120, BIOE121, and BIOE241.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE453, CHBE457, or ENMA425.
Examination of the structure and function of natural biomaterials, and cell-extracellular matrix interactions. Study physical properties of synthetic biomaterials for biomedical applications. Understanding molecular level interactions between biomolecules and biomaterials to design novel biomaterials with desirable characteristics. Application of biomaterials as implants, drug delivery systems, biosensors, engineered materials such as artificial skin and bone growth scaffolds will be covered.
BIOE457
(Perm Req)
Biomedical Electronics & Instrumentation
Credits: 4
Grad Meth: Reg, P-F, Aud
Prerequisite: BIOE120, BIOE121, BIOE241, PHYS261, MATH246, and PHYS260.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Students learn fundamental concepts of electronics, assembly of electronic components into functional circuits, and integration of functional electronic devices and circuits into a system. In the lab component, students will learn to assemble and evaluate circuits and systems.
BIOE461
(Perm Req)
Synthetic Biology and Biological Engineering
Credits: 3
Grad Meth: Reg, P-F
Prerequisite: BIOE120, BIOE121, BIOE241, and MATH246; or permission of ENGR-Fischell Department of Bioengineering department.
Recommended: Completion of BSCI222 and/or BSCI330 recommended.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Students are introduce to the scientific foundation and concepts of synthetic biology and biological engineering. Current examples that apply synthetic biology to fundamental and practical challenges will be emphasized. The course will also address the societal issues of synthetic biology, and briefly examine interests to regulate research in this area.
BIOE462
(Perm Req)
Therapeutic Development and Delivery
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: BIOE120, BIOE121, BIOE241, MATH246, and BSCI330; and must have completed or be concurrently enrolled in BIOE340.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Credit only granted for: BIOE489P or BIOE462.
Formerly: BIOE489P.
The ultimate purpose of the pharmaceutical and biotechnology industries is the development and delivery of therapeutics. This course covers fundamentals of engineering and the pharmaceutical sciences related to therapeutics, including basic pharmaceutics/drug delivery, pharmacokinetics, biomolecular kinetics, and regulatory issues. Specific focus is placed on biotherapeutics, including antibodies and protein engineering,RNA and DNA therapeutics (gene therapy and RNAi), extracellular vesicle biotechnology (exosomes), and cell-based therapies, including stem cells. The use of delivery technologies to enable therapeutics (e.g. nanomedicine) will also be discussed.
BIOE474
(Perm Req)
Biopharmaceutical Process Development and Manufacturing
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: BIOE120.
Restriction: Must have earned a minimum of 60 credits, Permission of ENGR-Fischell Department of Bioengineering department.
Jointly offered with: BIOE674.
Credit only granted for: BIOE474, BIOE674, CHBE474, BIOE489T, or BIOE689E.
Formerly: BIOE489T.
Covers the fundamental steps involved in process development and manufacturing of biopharmaceuticals. An overview of different classes of biopharmaceuticals as well as manufacturing requirements for clinical development and regulatory approval will be provided. In depth coverage of manufacturing steps including cell culture, purification and formulation as well as drug product manufacturing, analysis and stability will be covered. Scientific literature will be used to highlight current challenges and novel solutions in each step of the manufacturing process. Scale up considerations, GMP requirements and process economics will also be introduced.
BIOE485
(Perm Req)
Capstone Design I: Entrepreneurship, Regulatory Issues, and Ethics
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisite: 21 credits in BIOE courses; and must have completed or be concurrently enrolled in BIOE457.
Restriction: Permission of ENGR-Fischell Department of Bioengineering department; and senior standing; and must be in Engineering: Bioengineering program.
This is the first part of a two-semester senior capstone design course which covers principles involved in engineering design, design approaches, economics of design, ethics in engineering, and patent regulations. It also helps students learn team work and write design project proposals under the mentorship of a faculty advisor.

A Fearless Ideas Course from the Academy for Innovation & Entrepreneurship (AIE): http://ter.ps/iamFEARLESS Click here for more information on the Fearless Ideas Courses.
BIOE488B
(Perm Req)
Research Methods in Bioengineering; Biotechnology
Credits: 3
Grad Meth: Reg, P-F, Aud
Prerequisites: BIOE120, BIOE121, and BSCI330. Restriction: permission of department.

This course prepares students for a broad range of opportunities by delivering a practical, hands-on experience appropriate for a student interested in biotechnology. Students will gain exposure to: recombinant DNA, cell culture, transfection/transformation, and molecular biology assayssuch as: PCR/sequencing, gels/blots, reporter gene expression. This course provides students with a working research laboratory environment experience.
BIOE489H
(Perm Req)
Special Topics in Bioengineering; Bioengineering Honors Seminar
Credits: 1 - 3
Grad Meth: Reg, P-F, Aud
Restricted to students in the BIOE Honors Proram.
BIOE605
(Perm Req)
BIOE Graduate Studies I
Credits: 1
Grad Meth: Reg
Restriction: Must be in ENGR: PhD Only-Bioengineering (Doctoral) program.
Introduction to the bioengineering graduate program. Students gain exposure to departmental research through lab rotation and to current research in the field through seminar. Students will also gain preparation and guidance on other first-year academic requirements.
BIOE608
(Perm Req)
Bioengineering Seminar Series
Credits: 1
Grad Meth: S-F, Aud
For BIOE majors only.
BIOE610
(Perm Req)
Mathematical Methods in Bioengineering
Credits: 3
Grad Meth: Reg, Aud
Restriction: Permission of ENGR-Fischell Department of Bioengineering.
From diffusion problems to light-matter interactions, students will learn basic skills needed to create mathematical models in bioengineering. Students will first be exposed to simplified problems in analytical form, and then more complex problems with the help of computer software programs.
BIOE612
(Perm Req)
Physiological Evaluation of Bioengineering Designs
Credits: 3
Grad Meth: Reg, Aud
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Bioengineering designs of biomaterials, biomedical devices, imaging and drug delivery agents, tissue engineering, prosthesis (among others), offer the opportunity to improve health care. This course is aimed at providing knowledge to lead bioengineering designs on the basis of biocompatibility and to provide tools to assess their patho-physiological impact in biological systems.
BIOE651
(Perm Req)
Applied Mathematics in Bioengineering
Credits: 3
Grad Meth: Reg, Aud
Restriction: Restricted to Master's of Engineering - Bioengineering students; or permission of Fischell Department of Bioengineering.
Credit only granted for: BIOE651 or BIOE658M.
Formerly: BIOE658M.
Students will use and learn mathematical concepts that are directly relevant to their career as a bioengineer. They will apply these concepts to various bioengineering applications while also learning industry-relevant analytical software.
BIOE658J
(Perm Req)
Special Topics in Bioengineering (M.Eng.); Introduction to Programming and Data Analysis using Python
Credits: 3
Grad Meth: Reg
Restriction: For Master of Engineering students only or with permission of department.

Aims to provide an introduction to structured programming, computational methods, and data analysis techniques, with the goal of equipping students with a foundation that allows them to confidently tackle problems in research and industry. The course begins with basic programming concepts such as data types, operators, logical flow control, debugging, and computational complexity using Python. It then delves into more advanced topics such as dynamic programming, algorithms, and object-oriented programming. Students will also be introduced to effective tools and libraries for data analysis and visualization. Towards the end of the course, there will be an overview of machine learning, artificial intelligence, neural networks, and convolution neural networks, along with some useful libraries and modules.
BIOE658R
(Perm Req)
Special Topics in Bioengineering (M.Eng.); Regulatory Affairs in Medical Product Development
Credits: 3
Grad Meth: Reg, Aud
For Master of Engineering students only or with permission of department. Credit will only be granted for ANTH627 or BIOE658R.

An introductory course on regulations associated with the development and production of medical devices and pharmaceuticals.
BIOE674
(Perm Req)
Biopharmaceutical Process Development and Manufacturing
Credits: 3
Grad Meth: Reg, Aud
Restriction: Permission of ENGR-Fischell Department of Bioengineering department.
Jointly offered with: BIOE474.
Credit only granted for: BIOE674, BIOE474, CHBE474, BIOE489T, or BIOE689E.
Formerly: BIOE689E.
Covers the fundamental steps involved in process development and manufacturing of biopharmaceuticals. An overview of different classes of biopharmaceuticals as well as manufacturing requirements for clinical development and regulatory approval will be provided. In depth coverage of manufacturing steps including cell culture, purification and formulation as well as drug product manufacturing, analysis and stability will be covered. Scientific literature will be used to highlight current challenges and novel solutions in each step of the manufacturing process. Scale up considerations, GMP requirements and process economics will also be introduced.
BIOE689
(Perm Req)
Special Topics in Bioengineering
Credits: 1 - 3
Grad Meth: Reg
Contact department for information to register for this course.
BIOE689F
(Perm Req)
Special Topics in Bioengineering; Spatial Biology: Bioinformatics, Omics, and Technology
Credits: 3
Grad Meth: Reg
Restrictions: Permission of the Fischell Department of Bioengineering

Introduction to modern spatial biology methods, beginning with clinical motivations and pathology, moving to the materials, imaging, and chemistries that enable spatial methods, and ending with spatial omics analysis and bioinformatics. This course will cover clinical and engineering background and theory, and practical spatial omics programming and analysis.
BIOE689G
(Perm Req)
Special Topics in Bioengineering; Advanced Immunoengineering
Credits: 3
Grad Meth: Reg
Immunoengineering harnesses immunological functions to design treatments for various diseases including cancer. We will explore how engineering technologies have been used to study and modulate immune functions, techniques used in immunology and immune engineering, and new developments in the field. The course will largely focus on current literature in immune engineering topics.
BIOE689J
(Perm Req)
Special Topics in Bioengineering; Therapeutic Development and Delivery
Credits: 3
Grad Meth: Reg
BIOE799
(Perm Req)
Master's Thesis Research
Credits: 1 - 6
Grad Meth: S-F
Contact department for information to register for this course.
BIOE898
(Perm Req)
Pre-Candidacy Research
Credits: 1 - 8
Grad Meth: Reg
Contact department for information to register for this course.
BIOE899
(Perm Req)
Doctoral Dissertation Research
Credits: 6
Grad Meth: S-F
Contact department for information to register for this course.